Effects of anabolic agents on protein breakdown in L6 myoblasts
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چکیده
منابع مشابه
C1 Fluxes in L6 Myoblasts
Efflux of 3 G C1 ions was followed in undifferentiated L6 myoblasts at rest and after exposure to hypotonic saline in order to test participation of the chloride exit in regulatory volume decrease mechanism. The efflux curve can be fitted at least with two t ime constants. After the hypotonic stress the slow rate constant increases almost threefold, from 0.021 ±0.019 m i n 1 normal saline to 0....
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The existence of a large conductance voltage sensitive chloride channel is documented in undifferentiated cells (myoblasts) of the L6 rat muscle cell line. At this stage of development the resting membrane conductance is dominated by potassium ions only (Kidokoro 1975). The conductance of the channel in symmetrical 120 mmol/l choline chloride is 331 +/- 4 pS. The probability of the channel bein...
متن کاملRegulatory volume decrease in cultured myoblasts L6.
A method is described for measuring volume changes in single L6 myoblasts at a stage of proliferating "myoballs", which allows to follow volume changes on single cell level by means of quantitative video image analysis. Myoblasts exposed to hypoosmotic or hyperosmotic challenges for up to 3-5 min behave as osmometers. The relative cell volume is a linear function of the reciprocal of the relati...
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Clinical and experimental studies have implicated high circulating levels of the cytokine tumour necrosis factor-alpha (TNF-alpha) in the pathogenesis of insulin resistance, not only in obesity and diabetes, but also in clinical conditions associated with cachexia and sepsis. TNF-alpha impairs insulin-mediated glucose uptake in adipocytes, but because of lipolytic effects the interpretation of ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1983
ISSN: 0264-6021
DOI: 10.1042/bj2100243